Pre-Grant Publication Number: 20110097390
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Prior Art Detail
Summary / Description
| Summary / Description | Toll-like Receptor 3 and Geographic Atrophy in Age-Related Macular Degeneration |
Basic Information
| Type of Prior Art | Print Publication |
| Publication Title * | The New England Journal of Medicine |
| Author | Zhenglin Yang, M.D et al. |
| ISBN | |
| Page Range | 1456-1463 |
| Medium | Journal article |
| Publication Date * | October 2, 2008 |
| URL | |
Notes / To Do
| Notes | |
Excerpt
Excerpt Our data indicate that the T allele of SNP rs3775291 is associated with protection against geographic atrophy in patients with age-related macular degeneration and that this protective effect is probably mediated by a reduction of dsRNA-induced cell death in retinal pigment epithelial cells in vitro and in vivo. We did not find an association between SNPs in TLR3 and choroidal neovascularization or early age-related macular degeneration. TLR3 therefore seems to affect the geographic atrophy phenotype in particular. This association was evident only when controls were limited to persons with no drusen (as in the Utah case–control series) or fewer than five small drusen (as specified in AREDS category 1). Persons with five or more small drusen or changes in the retinal pigment epithelium (sometimes considered to be in the normal range) were not included in the study, suggesting that the TLR3 genotype is potentially implicated in early events in the pathogenesis of age-related macular degeneration. We speculate that although HTRA1 and CFH predispose persons to early and late age-related macular degeneration, TLR3 activation (which is enhanced with the 412Leu variant) might promote progression to the geographic atrophy phenotype. |
Relevance
Claims
1
Relevance
This paper talks about geographic atrophy, and the affects that tlr3 has on it. It also talks about dsRNA and its relationship to TLR3 and macular degeneration.
This paper talks about geographic atrophy, and the affects that tlr3 has on it. It also talks about dsRNA and its relationship to TLR3 and macular degeneration.
Claim Chart
Some
2
Relevance
Same as above.
Same as above.
Claim Chart
Some
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