Pre-Grant Publication Number: 20110111009
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Prior Art Detail
Summary / Description
| Summary / Description | Liposome encapsulation of nystatin for use in treatment of Systemic Yeast infection |
Basic Information
| Type of Prior Art | Print Publication |
| Publication Title * | |
| Author | Mehta et al. |
| ISBN | |
| Page Range | |
| Medium | Book excerpt |
| Publication Date * | December 1, 1987 |
| URL | http://www.ncbi.nlm.nih.gov/pmc... |
Notes / To Do
| Notes | |
Excerpt
Excerpt p.1897, col.2: "Phospholipids DMPC-DMPG (7:3), at a constant amount, were mixed with increasing amounts of the drug, and the organic solvents were evaporated under vacuum by using a rotary evaporator. The dried lipid-drug film was suspended in phosphate-buffered saline (PBS) and hand shaken, allowing the film to form liposomes. The suspensions were then centrifuged at 100,000 x g for 1 h. The pellets were resuspended in PBS, and the amount of NYS incorporated in liposomes was determined by dissolving a known volume in methanol and measuring A306. Similarly, liposomes composed of phospholipids and sterols at a ratio of 9:1 were also prepared." |
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Claims
1
Relevance
[[Claim 1]] pertains to a dry liposome of a water insoluble drug (nystatin is water insoluble) combination of: 1. an emulsifier (example given as a phospholipid in [[Reference 1]]) 2. a plant derived sterol or ester thereof (source of sterol not provided in [[reference 1]], however more than likely that it is from a plant source) 3. calcium salt (PBS as used in [[Reference 1]] can have dissolved calcium salt)
[[Claim 1]] pertains to a dry liposome of a water insoluble drug (nystatin is water insoluble) combination of: 1. an emulsifier (example given as a phospholipid in [[Reference 1]]) 2. a plant derived sterol or ester thereof (source of sterol not provided in [[reference 1]], however more than likely that it is from a plant source) 3. calcium salt (PBS as used in [[Reference 1]] can have dissolved calcium salt)
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13
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