Pre-Grant Publication Number: 20100311694
Set of geldanamycin derivatives and their preparation methods
Filing Date: January 19, 2009Priority Date: January 19, 2009
Inventors: Zhuorong Li, Zonggen Peng, Yanping Li, Jianhua Zhu, Peizhen Tao, Bo Fan, Yuping Wang, Guangzhi Shan, Shuqin Wang, Tian Zhang, Jiandong Jiang
Assignee(s): Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
Current U.S. Classification: 514, 514/080000, 540, 540/461000
View Prior Art for Claim 00010
The pharmaceutical compositions of the compounds shown in Formula (I) of Claim 1, wherein said compositions consists of said compounds with therapeutically effective amount as the active components and one or more pharmacologically acceptable carriers.
#994Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling...and reduces orthotopic tumor growth.
Applies to Claims 1,10,11,12
Submitted by: Ryan O'QuinnLast updated: about 2 years ago
Title Clinical Cancer Research
ISBN
Description
This journal article published prior to the patent's Chinese filing date describes using 17-Nucleoside derivatives of geldanamycin in human pancreatic cancer cells. Significant anti-tumor effects were noted.
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