Pre-Grant Publication Number: 20100311694
Filing Date: January 19, 2009Priority Date: January 19, 2009
Inventors: Zhuorong Li, Zonggen Peng, Yanping Li, Jianhua Zhu, Peizhen Tao, Bo Fan, Yuping Wang, Guangzhi Shan, Shuqin Wang, Tian Zhang, Jiandong Jiang
Assignee(s): Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences
Current U.S. Classification: 514, 514/080000, 540, 540/461000
Abstract
A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the manufacture of heat shock protein 90 (Hsp 90) inhibiting agents which have the utility as antivirus and antitumor agents.
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