Discloses fluorescent-based nanoparticles for the detection, diagnosis, or treatment of disease or conditions, for example in intact or living cells, which comprises a core comprising a fluorescent silane compound and a silica shell on the core.

discloses nano-sized silica has been developed adn been considered to be used in bone regeneration, and this paper evaluate the suitability of silica nanospheres for supporting osteoblast cell growth and metabolism

Tiejun Gao, Hannu T. Aro, Heimo Ylanen, Eero Vuorio, Silica-based bioactive glasses modulate expression of bone morphogenetic protein-2 mRNA in Saos-2 osteoblasts in vitro, Biomaterials, Volume 22, Issue 12, 15 June 2001, Pages 1475-1483. Silica based glasses modulate expression of bone mRNA in osteoblasts.